Latest Scientific Papers

Clinical Trial Publications:

Maria Benito, MD; Branimir Vasilic, Ph.D; Felix W Wehrli, Ph.D; Ben Bunker; B.A.; Michael Wald; B.A.; Bryon Gomberg, Ph.D; Alexander C Wright, Ph.D; Babette Zemel, Ph.D; Andrew Cucchiara, Ph.D; PeterJ. Snyder, MD, Effect of Testosterone Replacement on Trabecular Architecture In Hypogonadal Men, Journal of Bone and Mineral Research. 20(10), 2005.

G. A. Ladinsky, B. Vasilic, A. M. Popescu, B. Zemel, A. C. Wright, H. K. Song, P. K. Saha, H. Peachy, P. J. Snyder, F. W. Wehrli, MRI Based Virtual Bone Biopsy Detects Large One-Year Changes in Trabecular Bone Architecture of Early Postmenopausal Women, ASBMR 2005, Nashville, TN

Gomberg BR, Wehrli FW, Vasilic B, Weening RH, Saha PK, Song HK, and Wright AC, Reproducibility and error sources of Micro-MRI-based trabecular bone structural parameters of the distal radius and tibia, Bone 35 (2004) 266– 276.

Felix W. Wehrli, Mary B. Leonard, Punam K. Saha and Bryon R. Gomberg, Quantitative High-Resolution Magnetic Resonance Imaging Reveals Structural Implications of Renal Osteodystrophy on Trabecular and Cortical Bone, Journal of Magnetic Resonance Imaging 2004;20:83 –89.

Maria Benito, Bryon Gomberg, Felix W. Wehrli, Richard H. Weening, Babette Zemel, Alexander C. Wright, Hee Kwon Song, Andrew Cucchiara, and Peter J. Snyder, Deterioration of Trabecular Architecture in Hypogonadal Men, The Journal Of Clinical Endocrinology & Metabolism 88(4):1497–1502.

Wehrli FW, Popescu AM, Vasilic B, Gomberg BR, Saha PK, Zemel B, Bunker B, Wright AC, Snyder PJ, Peachey H, Longitudinal Changes in Trabecular Bone Architecture Detected by Micro-MRI Based Virtual Bone Biopsy, American Society for Bone & Mineral Research, 25th Annual Meeting, Minneapolis MI, 2003

Wehrli FW, Gomberg BR, Saha PK, Song HK, Hwang SN, Snyder PJ, Digital Topological Analysis of In Vivo Magnetic Resonance Microimages of Trabecular Bone Reveals Structural Implications of Osteoporosis, Journal of Bone & Mineral Research. 16(8):1520-31, 2001 Aug.

Technical Publications:

Gomberg BR, Saha PK, Wehrli FW, Method for cortical bone structural analysis from magnetic resonance images, Academic Radiology. 12:1320-1332, 2005.

Wehrli, F. W., K. P. Saha, Bryon R. Gomberg, Hee Kwon Song, Peter J. Snyder, Maria Benito, Alex Wright, Richard Weening, Role of Magnetic Resonance for Assessing Structure and Function of Trabecular Bone, Topics in Magnetic Resonance Imaging 13(5): 335-355.

Bryon R. Gomberg, Punam K. Saha, Scott N. Hwang, Hee Kwon Song, and Felix W. Wehrli, >Integrated Processing System for In Vivo MR Images of Trabecular Bone Networks, ISMRM 9th Meeting and Exhibition, Glasgow, Scotland, 2001.

Gomberg BR, Saha PK, Song HK, Hwang SN, Wehrli FW, Topological Analysis of Trabecular Bone MR Images, IEEE Transactions on Medical Imaging. 19(3):166-74, 2000 Mar.

Three Dimensional Topology Publications:

Bryon R. Gomberg, Punam K. Saha, and Felix W. Wehrli, Topology-based Orientation Analysis of Trabecular Bone Networks, Medical Physics, Vol. 30, No. 2, February 2003.

Punam K. Saha, Fuzzy Distance Transform: Theory, Algorithms, and Applications, Computer Vision and Image Understanding 86, 171–190 (2002).

Punam K. Saha, Bryon R. Gomberg, Felix W. Wehrli, Three-Dimensional Digital Topological Characterization of Cancellous Bone Architecture, International Journal of Imaging Systems & Technology, Vol. 11, 81–90 (2000).

Scott H. Hwang, Felix W. Wehrli, Probability Based Structural Parameters from Three Dimensional Nuclear Magnetic Resonance as Predictors of Trabecular Bone Strength, Med Phys 24 (8), August 1997.

Punam K. Saha, 3D Digital Topology under Binary Transformation with Applications, Computer Vision And Image Understanding, Vol. 63, No. 3, May, pp. 418–429, 1996.

Scott H. Hwang, Felix W. Wehrli, Estimating Voxel Volume Fractions of Trabecular Bone on the Basis of Magnetic Resonance Images Acquired In-vivo, International Journal of Imaging Systems & Technology, Vol. 10, 186-198 (1999).

Acquisition Method Publications:

A. Techawiboonwong, HK Song, JF Magland, PK Saha, FW Wehrli, Implications of Pulse Sequence in Structural Imaging of Trabecular Bone, JMRI 22:647-655 (2005)

Jingfei Ma, Felix W. Wehrli, Hee Kwon Song, Fast 3D Large-angle Spin-echo Imaging (3D FLASE), Magnetic Resonance in Medicine 35: 903-910.

Song, H. K. and F. W. Wehrli, In Vivo Micro-imaging Using Alternating Navigator Echoes with Applications to Cancellous Bone Structural Analysis, Magnetic Resonance in Medicine 41: 947-953.

Image Processing Publications:

Scott H. Hwang, Felix W. Wehrli, Subvoxel Processing: A Method for Reducing Partial Volume Blurring With Application to In Vivo MR Images of Trabecular Bone, Magnetic Resonance in Medicine 47:948–957 (2002).

Saha, P.K., B.B. Chaudhuri, and D. Duuta Majumder, A New Shape Preserving Parallel Thinning Algorithm for 3D Digital Images, Pattern Recognition 30, 1939-1955.